Endocrine Abstracts

Introduction: Vitamin D deficiency (25OHD) is common in women with polycystic ovary syndrome (PCOS). 67–85% of female patients with PCOS have low concentration level of 25OHD (<20 ng/ml). It is believed that low concentration levels of 25OHD may exacerbate the symptoms of PCOS.Aim: The aim of the study was to evaluate the concentration of 25OHD in women diagnosed with PCOS and the analysis of the relationship between 25OHD concentration and such...

Agranulocytosis is an uncommon but very serious complication during treatment with thyrostatic. In case of severe hyperthyroidism removal of circulating thyroid hormones by plasmapheresis may be an effective therapeutic option.We present the therapeutic difficulties and successful treatment with preoperative plasmapheresis in 63-year-old female patient with severe hyperthyroidism in the course of toxic nodular goiter and agranulocytosis, which occurred a...

Introduction: Pheochromocytoma is usually benign neuroendocrine tumor arising from chromaffin cells. Malignant tumors which account for 5–26% mainly metastize to bones, lungs, liver, but very rarely to brain. The coexistence of pheochromocytoma with brain meningioma may hinder the diagnosis.Aim: The aim of this study is to present the case of a malignant pheochromocytoma female with brain metastases and coexisting meningioma.C...

Introduction: Fine needle aspiration biopsy (FNAB) plays a crucial role in the diagnosis of thyroid nodules. The choice of further therapeutic strategy depends largely on its result. Knowledge of the risk of malignancy in each diagnosis class in the population is necessary. The aim of the research was to analyse the risk of malignancy in thyroid nodules in each diagnosis class according to Bethesda system.Materials and methods: Retrospective research inc...

A 67-year-old male with PTC (pT3N0) underwent a total thyroidectomy in February 2004. Subsequently he was treated with I-131 and radiotherapy (RT). Combined therapy did not normalize the serum thyroglobulin (TG). Because of elevated TG and persistent I-131 uptake in thyroid bed the patient received a total activity of 21275 MBq of I-131 in 4 years. The treatment was stopped in March 2007 due to a lack of I-131 uptake in the last post-therapeutic whole body scan (WBS) with stil...

Background: The so called “big-big” prolactin, also known as macroprolactin is formed by prolactin-immunoglobulin complexes, and is considered to be biologically inactive. Nevertheless, macroprolactin may cause elevation of serum prolactin (Prl) concentrations measured by standard assays. In women presenting with oligo- and/or amenorrhoea the cause of menstrual irregularity needs to be explained even in the setting of concomitant macroprolactinaemia. We have therefor...

Macroprolactin is formed by prolactin-immunoglobulin complexes and may cause elevation of prolactin (Prl) concentrations, potentially leading to unnecessary investigations and/or treatment. We have endeavoured to assess the prevalence of macroprolactinaemia in euthyroid women with non-toxic goitre and to assess whether autoimmune thyroid disease may result in an increased prevalence of macroprolactinaemia.Material & Methods: We measured serum Prl in ...

Introduction: Prolactin is a hormone which is characterized with a high structural and functional polymorphism. Macroprolactin is one of the form of prolactin - it is a complex of monomeric prolactin and immunoglobulin. Macroprolactin is characterized with immunoreactivity and probably the lack of biological activity.Purpose: The main purpose of our study was to estimate the frequency of macroprolactin appearance among the patients with hyperpronactinaem...

Introdutcion: In recent years, thyroid microcarcinoma (TMC) predominates in the context of diagnosis and treatment of thyroid cancer. TMC has an excellent prognosis, its management is changed in the last few years, reducing surgical procedure and role of radioiodine ablation (RAI). Therefore, the question is what tests have a diagnostic value in patients with thyroid microcarcinoma after thyroidectomyThe aim of this study was to evaluate the role of 131 ...

Introduction: Adrenocorticotropic hormone (ACTH) is a tropic hormone produced by the anterior pituitary that stimulates the adrenal glands to release cortisol. The ACTH measurement is often used to diagnose the pituitary and/or adrenal disorders, mainly Cushing’s disease, Cushing’s syndrome, Addison’s disease and hypopituitarism. Therefore, the assessment of plasma ACTH concentration is a crucial step in the differential diagnosis of hypothalamic–pituitary&...